To my knowledge when you talk about the plugin version of Ctrlr it does not matter if you have a multiclient capable midi interface. The DAW and the Ctrlr plugin won’t ever be able to use both the same port. That’s why the options “Output to plugin host” and “Input from host” are there. Unfortunately in Cubase “Output to host” does not work. The only DAW I know that this works somewhat as expected is Reaper.
With my SuperJX v4.x panel the plugin version of Ctrlr won’t give you any advantages compared to the standalone version. Well, except parameter automation. Ctrlr standalone works well in parallel with any DAW as long as you have a multiclient midi interface. Btw. on Mac all interfaces are multiclient. So I would recommend you to try out Ctrlr standalone.